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US biomedical and medical research under the Trump administration
Authors: Paul Webster
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Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial
Authors: Stephen A. Harrison | Peter J. Ruane | Bradley L. Freilich | Guy Neff | Rashmee Patil | Cynthia A. Behling | Chen Hu | Erica Fong | Brittany de Temple | Erik J. Tillman | Timothy P. Rolph | Andrew Cheng | Kitty Yale
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Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
Authors: Wolfram Jochum | Jean-Pierre David | Candace Elliott | Anton Wutz | Hanns Plenk | Koichi Matsuo | Erwin F. Wagner
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A first step toward in vivo gene editing in patients
Authors: Hildegard Büning | Axel Schambach
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Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes
Authors: Rongrong Fan | Amine Toubal | Saioa Goñi | Karima Drareni | Zhiqiang Huang | Fawaz Alzaid | Raphaelle Ballaire | Patricia Ancel | Ning Liang | Anastasios Damdimopoulos | Isabelle Hainault | Antoine Soprani | Judith Aron-Wisnewsky | Fabienne Foufelle | Toby Lawrence | Jean-Francois Gautier | Nicolas Venteclef | Eckardt Treuter
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Gateway to the metabolic syndrome
Authors: Gema Medina-Gomez | Antonio Vidal-Puig
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Institutional review boards need new skills to review data sharing and management plans
Authors: Vasiliki Rahimzadeh | Kimberley Serpico | Luke Gelinas
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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases
Authors: Jing Ni | Shakti H Ramkissoon | Shaozhen Xie | Shom Goel | Daniel G Stover | Hanbing Guo | Victor Luu | Eugenio Marco | Lori A Ramkissoon | Yun Jee Kang | Marika Hayashi | Quang-De Nguyen | Azra H Ligon | Rose Du | Elizabeth B Claus | Brian M Alexander | Guo-Cheng Yuan | Zhigang C Wang | J Dirk Iglehart | Ian E Krop | Thomas M Roberts | Eric P Winer | Nancy U Lin | Keith L Ligon | Jean J Zhao
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Platelets mediate cytotoxic T lymphocyte–induced liver damage
Authors: Matteo Iannacone | Giovanni Sitia | Masanori Isogawa | Patrizia Marchese | Maria G Castro | Pedro R Lowenstein | Francis V Chisari | Zaverio M Ruggeri | Luca G Guidotti
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Targeting the innate immune response with improved vaccine adjuvants
Authors: Achal Pashine | Nicholas M Valiante | Jeffrey B Ulmer
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Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo
Authors: Brent A Hanks | Jianghong Jiang | Rana A K Singh | Weitao Song | Michael Barry | Mary H Huls | Kevin M Slawin | David M Spencer
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NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway
Authors: Julia Skokowa | Dan Lan | Basant Kumar Thakur | Fei Wang | Kshama Gupta | Gunnar Cario | Annette Müller Brechlin | Axel Schambach | Lars Hinrichsen | Gustav Meyer | Matthias Gaestel | Martin Stanulla | Qiang Tong | Karl Welte
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A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation
Authors: Dongsheng Duan | Yongping Yue | Ziying Yan | John F. Engelhardt
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TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Authors: Roberto Baccala | Kasper Hoebe | Dwight H Kono | Bruce Beutler | Argyrios N Theofilopoulos
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ORP150 protects against hypoxia/ischemia-induced neuronal death
Authors: Michio Tamatani | Tomohiro Matsuyama | Atsushi Yamaguchi | Noriaki Mitsuda | Yoshitane Tsukamoto | Manabu Taniguchi | Yong Ho Che | Kentaro Ozawa | Osamu Hori | Hiroyuki Nishimura | Atsuko Yamashita | Masaru Okabe | Hideki Yanagi | David M. Stern | Satoshi Ogawa | Masaya Tohyama
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Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
Authors: Sam E Day | Mikko I Kettunen | Ferdia A Gallagher | De-En Hu | Mathilde Lerche | Jan Wolber | Klaes Golman | Jan Henrik Ardenkjaer-Larsen | Kevin M Brindle
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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
Authors: Takahiro Karasaki | David A. Moore | Selvaraju Veeriah | Cristina Naceur-Lombardelli | Antonia Toncheva | Neil Magno | Sophia Ward | Maise Al Bakir | Thomas B. K. Watkins | Kristiana Grigoriadis | Ariana Huebner | Mark S. Hill | Alexander M. Frankell | Christopher Abbosh | Clare Puttick | Haoran Zhai | Francisco Gimeno-Valiente | Sadegh Saghafinia | Nnennaya Kanu | Michelle Dietzen | Oriol Pich | Emilia L. Lim | Carlos Martínez-Ruiz | James R. M. Black | Dhruva Biswas | Brittany B. Campbell | Claudia Lee | Emma Colliver | Katey S. S. Enfield | Sonya Hessey | Crispin T. Hiley | Simone Zaccaria | Kevin Litchfield | Nicolai J. Birkbak | Elizabeth Larose Cadieux | Jonas Demeulemeester | Peter Van Loo | Prasad S. Adusumilli | Kay See Tan | Waseem Cheema | Francisco Sanchez-Vega | David R. Jones | Natasha Rekhtman | William D. Travis | Allan Hackshaw | Teresa Marafioti | Roberto Salgado | John Le Quesne | Andrew G. Nicholson | Peter Van Loo | John Le Quesne | Jason F. Lester | Amrita Bajaj | Apostolos Nakas | Azmina Sodha-Ramdeen | Keng Ang | Mohamad Tufail | Mohammed Fiyaz Chowdhry | Molly Scotland | Rebecca Boyles | Sridhar Rathinam | Claire Wilson | Domenic Marrone | Sean Dulloo | Dean A. Fennell | Gurdeep Matharu | Jacqui A. Shaw | Joan Riley | Lindsay Primrose | Ekaterini Boleti | Heather Cheyne | Mohammed Khalil | Shirley Richardson | Tracey Cruickshank | Gillian Price | Keith M. Kerr | Sarah Benafif | Kayleigh Gilbert | Babu Naidu | Akshay J. Patel | Aya Osman | Christer Lacson | Gerald Langman | Helen Shackleford | Madava Djearaman | Salma Kadiri | Gary Middleton | Angela Leek | Jack Davies Hodgkinson | Nicola Totten | Angeles Montero | Elaine Smith | Eustace Fontaine | Felice Granato | Helen Doran | Juliette Novasio | Kendadai Rammohan | Leena Joseph | Paul Bishop | Rajesh Shah | Stuart Moss | Vijay Joshi | Philip Crosbie | Fabio Gomes | Kate Brown | Mathew Carter | Anshuman Chaturvedi | Lynsey Priest | Pedro Oliveira | Colin R. Lindsay | Fiona H. Blackhall | Matthew G. Krebs | Yvonne Summers | Alexandra Clipson | Jonathan Tugwood | Alastair Kerr | Dominic G. Rothwell | Elaine Kilgour | Caroline Dive | Hugo J. W. L. Aerts | Roland F. Schwarz | Tom L. Kaufmann | Gareth A. Wilson | Rachel Rosenthal | Zoltan Szallasi | Judit Kisistok | Mateo Sokac | Miklos Diossy | Abigail Bunkum | Aengus Stewart | Alastair Magness | Andrew Rowan | Angeliki Karamani | Benny Chain | Carla Castignani | Chris Bailey | Clare E. Weeden | Corentin Richard | David R. Pearce | Despoina Karagianni | Dina Levi | Elena Hoxha | Emma Nye | Eva Grönroos | Felip Gálvez-Cancino | Foteini Athanasopoulou | George Kassiotis | Georgia Stavrou | Gerasimos Mastrokalos | Helen L. Lowe | Ignacio Garcia Matos | Jacki Goldman | James L. Reading | Javier Herrero | Jayant K. Rane | Jerome Nicod | Jie Min Lam | John A. Hartley | Karl S. Peggs | Kayalvizhi Selvaraju | Kerstin Thol | Kevin W. Ng | Kezhong Chen | Krijn Dijkstra | Krupa Thakkar | Leah Ensell | Mansi Shah | Marcos Vasquez Duran | Maria Litovchenko | Mariana Werner Sunderland | Michelle Leung | Mickael Escudero | Mihaela Angelova | Miljana Tanić | Monica Sivakumar | Olga Chervova | Olivia Lucas | Othman Al-Sawaf | Paulina Prymas | Philip Hobson | Piotr Pawlik | Richard Kevin Stone | Robert Bentham | Robert E. Hynds | Roberto Vendramin | Saioa López | Samuel Gamble | Seng Kuong Anakin Ung | Sergio A. Quezada | Sharon Vanloo | Stefan Boeing | Stephan Beck | Supreet Kaur Bola | Tamara Denner | Thanos P. Mourikis | Victoria Spanswick | Vittorio Barbè | Wei-Ting Lu | William Hill | Wing Kin Liu | Yin Wu | Yutaka Naito | Zoe Ramsden | Catarina Veiga | Gary Royle | Charles-Antoine Collins-Fekete | Francesco Fraioli | Paul Ashford | Tristan Clark | Martin D. Forster | Siow Ming Lee | Elaine Borg | Mary Falzon | Dionysis Papadatos-Pastos | James Wilson | Tanya Ahmad | Alexander James Procter | Asia Ahmed | Magali N. Taylor | Arjun Nair | David Lawrence | Davide Patrini | Neal Navani | Ricky M. Thakrar | Sam M. Janes | Emilie Martinoni Hoogenboom | Fleur Monk | James W. Holding | Junaid Choudhary | Kunal Bhakhri | Marco Scarci | Martin Hayward | Nikolaos Panagiotopoulos | Pat Gorman | Reena Khiroya | Robert CM. Stephens | Yien Ning Sophia Wong | Steve Bandula | Abigail Sharp | Sean Smith | Nicole Gower | Harjot Kaur Dhanda | Kitty Chan | Camilla Pilotti | Rachel Leslie | Anca Grapa | Hanyun Zhang | Khalid AbdulJabbar | Xiaoxi Pan | Yinyin Yuan | David Chuter | Mairead MacKenzie | Serena Chee | Aiman Alzetani | Judith Cave | Lydia Scarlett | Jennifer Richards | Papawadee Ingram | Silvia Austin | Eric Lim | Paulo De Sousa | Simon Jordan | Alexandra Rice | Hilgardt Raubenheimer | Harshil Bhayani | Lyn Ambrose | Anand Devaraj | Hema Chavan | Sofina Begum | Silviu I. Buderi | Daniel Kaniu | Mpho Malima | Sarah Booth | Nadia Fernandes | Pratibha Shah | Chiara Proli | Madeleine Hewish | Sarah Danson | Michael J. Shackcloth | Lily Robinson | Peter Russell | Kevin G. Blyth | Craig Dick | Alan Kirk | Mo Asif | Rocco Bilancia | Nikos Kostoulas | Mathew Thomas | Nicholas McGranahan | Charles Swanton | Mariam Jamal-Hanjani | TRACERx Consortium
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To screen or not to screen?
Authors: Karen O’Leary
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Publisher Correction: Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial
Authors: Hai-Qiang Mai | Qiu-Yan Chen | Dongping Chen | Chaosu Hu | Kunyu Yang | Jiyu Wen | Jingao Li | Ying-Rui Shi | Feng Jin | Ruilian Xu | Jianji Pan | Shenhong Qu | Ping Li | Chunhong Hu | Yi-Chun Liu | Yi Jiang | Xia He | Hung-Ming Wang | Wan-Teck Lim | Wangjun Liao | Xiaohui He | Xiaozhong Chen | Zhigang Liu | Xianglin Yuan | Qi Li | Xiaoyan Lin | Shanghua Jing | Yanju Chen | Yin Lu | Ching-Yun Hsieh | Muh-Hwa Yang | Chia-Jui Yen | Jens Samol | Hui Feng | Sheng Yao | Patricia Keegan | Rui-Hua Xu
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Reducing surgical site infections in low-resource settings
Authors: Karen O’Leary
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